The game of the round will be the all-Premier League clash between Aduana Stars and King Faisal.
Dreams FC, who are at this stage of the competition for the first time in their history, will play lower division side, Kotoku Royals in the other Southern Zone pairing, with Bechem United scheduled to play Tamale City FC.
Clubs will earn six thousand cedis for making it to this stage and a thousand cedis worth of airtime.
Speaking to the Chairman of the FA Cup Committee, Wilson Arthur says the draw is a good one and expects to see the best of performances from all the clubs.
MTN FA CUP DRAW
•Skyy FC vs Accra Hearts of Oak
•Dreams FC vs Kotoku Royals
• Bechem United vs Tamale City FC
• Aduana Stars vs King Faisal Babies FC
According to the Ghana Football Association, the date and venues for the games will be communicated shortly.